Announcements

Laboratory of Applied Pharmacokinetics

Previous announcements, proceedings, and teaching material

We would like to announce our upcoming premeeting workshop on Sunday April 3, 2011, just before the ACoP meetings in San Diego. Please see below.

ACoP Premeeting Worlshop – Sunday, April 3, 2011
Hotel Del Coronado, San Diego, CA

Using Pharmacometrics for Maximally Precise Individualized Drug Therapy with a Laptop at the Bedside or Nurses’ Station

This hands – on workshop is intended for physicians, pharmacists, clinical toxicologists and biomedical scientists with an interest in therapeutic drug monitoring, in population pharmacokinetic and pharmacodynamic modeling, and in optimal individualization of drug therapy for patient care. Prior experience in clinical pharmacokinetics will be an advantage. Participants will be introduced to the new MM-USC*PACK software, which will be compared with other approaches. This library of tools now provides the optimally precise approach for clinical therapeutic drug management as well as for population PK/PD and physiological modeling.

Participants are encouraged to bring their laptop computers to the workshop, and to download and install, well prior to the workshop, the demonstration software from our web site (www.lapk.org, click on software, click on downloads, and register by putting in your contact information). Participants will receive an email giving them access to download the software, so they can participate in the hands-on parts of the workshop with us. Please act fast. Regular enrollment apparently closes December 17! Please go to the ACoP web site, which is www.go-acop.org and register there.

Objectives and Expectations:

After this conference, the participant should:
1. Describe the General approach to Target-Oriented, Model Based, Individualized Drug Therapy,
2. Discuss the Clinical capabilities of Nonparametric Population Modeling.
3. Explain the need for using assay standard deviation rather than CV% in reporting lab errors.
4. Explain Multiple Model, maximally precise, Dosage Design.
5. Describe the four types of Bayesian individualization of Pharmacokinetic Models, and when to use them.
6. Summarize the features of models of bacterial growth and kill
7. Explain the new approaches to optimize learning about the patient while treating him/her at the same time.
8. Discuss recent improved outcomes using Bayesian adaptive control.
9. Apply these concepts to optimize practical therapy with Aminoglycosides, Vancomycin, Digoxin, HAART, and other drugs.

Faculty:
Roger Jelliffe, M.D., Professor of Medicine, Co-Director, USC Laboratory of Applied Pharmacokinetics, USC School of Medicine
Michael Neely, M.D., Assistant Professor of Pediatrics, and Co-Director, USC Laboratory of Applied Pharmacokinetics, USC School of Medicine

Morning - The Pharmacometric Tools, and some Clinical Cases

8:30 AM - Registration
9:00 AM - Welcome - Dr. Jelliffe
9:15 AM – Planning the Initial Regimen. Set a Specific Target, not a Range
– Dr. Jelliffe
9:30 AM –Hands on - Evaluating Changing Renal Function in Patients
- Dr. Jelliffe
9:50 AM –Hands on - Describing assay errors by Standard Deviation, not CV%
- Dr. Neely
10:00 AM – Stating Dosage and Drug Administration errors. Dr. Jelliffe

10:15 AM – Break

10:30 AM – Estimating mostly timing errors (the remaining Environmental Noise)
– Dr. Jelliffe
10:40 AM – Hands on - Nonparametric Population models – Dr. Neely
Why? – Properties, Capabilities, Data entry and output
11:15 AM - Hands on - MM Dosage Design – Dr. Jelliffe
11:45 AM – Hands on - Bayesian analysis – Dr. Jelliffe
MAP, MM, Hybrid, IMM

12:30 AM – Lunch

Afternoon - More Clinical Cases

2:00 PM – Hands on - Clinical Cases – Dr. Jelliffe
Plan a Gentamicin Regimen
Monitor a Gent Patient
2:30 PM - Hands on - TDM on a very unstable Tobramycin patient
2;45 pm - Using IMM Bayesian in post surgical ICU patients – Dr. Jelliffe

3:00 PM – Break

3:20 PM – Concentration versus Time Dependent Drugs – Dr. Neely
3:30 PM – Hands on - Clinical Cases - Vancomycin
A q 12 h schedule
A Continuous IV infusion schedule
3:50 PM - Hands on - Clinical Cases - Digoxin Therapy – Dr. Jelliffe
Digoxin Effect correlates not with serum levels, but with Peripheral Compartment Concentrations – the Reuning Model
Planning the Initial Regimen
Stating serum concentration target goals
Stating Peripheral Compartment target goals
Patients with Atrial Fibrillation and Flutter
The Falk Study in Patients with Atrial Fibrillation
Two patients with Atrial Fibrillation
4:15 PM - Individualized Therapy of Children and Adults with HIV – Dr. Neely
4:45 PM – Outcomes with Individualized Therapy – Dr. Jelliffe
5:15 PM - Modeling Bacterial (or viral) Growth and Kill – Dr. Neely

5:30 PM – Adjourn

A new version of MM-USCPACK is available

A new version of the clinical MM-USCPACK software is now available for download of the demonstration version, and for
all of you who have registered for our workshops in San Antonio on September 12, and in Montreal on October 9 and 10.

The new version can:

1. Make a hybrid Bayesian analysis of the patient data (download the stuff to see what this is in the explanation under "Advanced" and "Compute options"). It takes only a little longer, and it always has model support points where the patient data needs them. Better and safer Bayesian posteriors for unusual patients.

2. The interacting multiple model (IMM) sequential Bayesian procedure is also good for patients with changing model parameter values during the period of data analysis, to help model events in very unstable patients.

3. One can also exclude selected serum concentrations from the data when you fit, to examine the ability of the various Bayesian posterior individual models to predict the data during the time of the excluded data (Alison Thomson and Jason Roberts, this is especially for you!).

THE INTERNATIONAL ASSOCIATION FOR THERAPEUTIC DRUG MONITORING
AND CLINICAL TOXICOLOGY,
THE LABORATORY OF APPLIED PHARMACOKINETICS
at the University of Southern California School of Medicine,
and the HOSPITAL CIVIL DE GUADALAJARA, GUADALAJARA, MEXICO,
are pleased to announce:

A 2 DAY WORKSHOP ON

PHARMACOMETRIC TOOLS FOR PRACTICAL INDIVIDUALIZED DRUG DOSAGE REGIMENS - POPULATION PK/PD MODELING, MULTIPLE MODEL (MM) DOSAGE DESIGN, AND MM BAYESIAN ADAPTIVE CONTROL

THURSDAY AND FRIDAY, July 9-10, 2009,

Hospital Civil de Guadalajara
Guadalajara, Mexico

FOR FURTHER INFORMATION AND FOR REGISTRATION, PLEASE CONTACT

DR. JOSE PEREZ-URIZAR, phone / fax 011-52-444-813-3986,
email = jpurizar@uaslp.mx

This course is intended for physicians, pharmacists, clinical toxicologists and biomedical scientists with an interest in therapeutic drug monitoring, in population pharmacokinetic and pharmacodynamic modeling, and in optimal individualization of drug therapy for patient care. Prior experience in clinical pharmacokinetics will be an advantage. Participants will be introduced to the new MM-USC*PACK software, which will be compared with other approaches. This library of tools provides optimal (maximally precise) approaches for clinical therapeutic drug monitoring as well as for nonparametric population PK/PD modeling.

Participants are encouraged to bring their laptop computers to the workshop, and to download and install, in the days prior to the workshop, the demonstration software from our web site (www.lapk.org, click on software), so they can do the hands-on parts of the workshop with us.

Objectives and Expectations:

After this conference, the participant should be able to:
1. Explain the General approach to Target-Oriented, Model Based, Individualized Drug Therapy,
2. Understand and use the Clinical capabilities of Nonparametric Population PK Modeling.
3. Explain the need for using assay standard deviation rather than CV% in reporting lab errors.
4. Implement Multiple Model, maximally precise, Dosage Design.
5. Explain the four types of Bayesian individualization of Pharmacokinetic Models, and when to use them.
6. Become acquainted with models of bacterial growth and kill
7. Be acquainted with new approaches to optimize learning about the patient while treating him/her at the same time.
8. Be aware of recent improved outcomes using Bayesian adaptive control.
9. Apply these concepts to optimize practical therapy with Aminoglycosides, Vancomycin, Digoxin, and other drugs.

Faculty:
Dr. Amador Covarrubias Pinedo, Clinical Chairman, Hospital Civil de Guadalajara, Mexico, tel = 52 33 10 43 25 88
Dr. Roger Jelliffe, University of Southern California Laboratory of Applied Pharmacokinetics, Los Angeles, CA, USA
Dr. Jose Perez-Urizar, University of San Luis Potosi, Mexico

Day 1 - The Library of Tools, and some Clinical Cases

8:30 AM - Registration
9:00 AM - Welcome - Dr. Covarrubias Pinedo.
9:15 AM - Review of Basic Pharmacokinetic behavior - Dr. Perez-Urizar.
9:30 AM - TOOL #1 - Hands-on - Planning the Initial Regimen. Set a Specific Target, not a Range - Dr. Jelliffe.
9:45 AM - TOOL #2 - Hands-on - Evaluating Renal Function - Dr. Jelliffe.
10:00 AM - Contribution of Clinical Pharmacokinetics to Patient Care in a Teaching Hospital. - Dr. Perez-Urizar.

10:30 AM - Break

10:45 AM - TOOL #3 - Nonparametric (NP) Pop models - Dr. Jelliffe.
Why NP? - Properties, Capabilities
11:15 AM - TOOL #4 - Hands-on - Describing assay errors by Standard Deviation, not CV%.
11:30 AM - TOOL #5 - Estimating the remaining Environmental Noise.

11:45 AM - TOOL #6 - MM Dosage Design - Dr. Jelliffe.

12:30 AM - Lunch

1:30 PM - Hands-on - Entering and storing patient data - Drs. Jelliffe and Perez-Urizar.
2:00 PM -Monitoring the patient and the Regimen - Dr. Jelliffe.
Linear, Nonlinear Regression
2:15 PM - Bayes theorem - Dr. Jelliffe.
Use population model
State Dosage, assay, timing errors
2:30 PM - TOOL #7 - Four methods for Bayesian analysis - Dr. Jelliffe.
MAP, MM, Hybrid, IMM

3:00 PM - Break

3:20 PM - Using Bayes' Theorem to analyze patient data - Dr. Jelliffe.
3:50 PM - TOOL #8 - Adjusting the regimen - Dr. Jelliffe
4:00 PM - Hands-on Session - Clinical Cases - Drs. Jelliffe and Perez-Urizar.
Plan an Amikacin Regimen
Monitor and adjust dosage on an Amikacin Patient
4:20 PM - Hands-on - TDM on a very unstable Tobramycin patient - Drs. Jelliffe and Perez-Urizar.
4:45 PM - Outcomes with Individualized Therapy - Dr. Jelliffe.

5:15 PM - Adjourn

Day 2 - More Clinical Cases and Advanced Population Modeling

9:00 AM - Clinical Cases - Digoxin Therapy - Dr. Jelliffe.
Digoxin Effect correlates not with serum levels, but with Peripheral
Compartment Concentrations - the Reuning Model
Hands-on - Planning the Initial Regimen
Stating serum concentration target goals
Stating Peripheral Compartment target goals
Patients with Atrial Fibrillation and Flutter
The Falk Study in Patients with Atrial Fibrillation
A patient with Atrial Fibrillation

9:45 AM - Hands-on- Monitoring and adjusting dosage on a patient with Atrial Fibrillation - Drs Jelliffe and Perez-Urizar.
9:45 AM - Concentration versus Time Dependent Drugs - Dr. Jelliffe.
10:00 AM - Hands-on - Vancomycin - Drs Jelliffe and Perez-Urizar.
A q 12 h schedule
A Continuous IV infusion schedule

10:30 AM - Break

10:45 AM - More 0n Population Modeling - Consistency, Stochastic Convergence, Efficiency, Precision - Dr. Jelliffe
11:30 AM - Hands-on - Making an NPAG population model of an Aminoglycoside - Drs. Jelliffe and Perez-Urizar

12:30 PM - Lunch

2:00 PM - Hands-on Session - Planning and evaluating dosage regimens of Vancomycin - Drs. Jelliffe and Perez-Urizar
2:30 PM - Modeling Diffusion into Endocardial Vegetations - Dr. Jelliffe
3:00 PM - Modeling Bacterial (or viral) Growth and Kill. - Dr. Jelliffe

3:30 PM - Break

3:45 PM - Hands-on Session - Planning the Amikacin regimen again
For a 20 yr old patient
For a 65 yr old patient
4:30 PM - Outcomes with Individualized Therapy - Dr. Jelliffe
4:45 PM - Review and Discussion - All participants.

5:15 PM - Adjourn

Due to the unfortunate outbreak of the H1N1 virus in Mexico, the 2 day workshop at The Hospital Civil De Guadalajara, Guadalajara, Mexico, on pharmacometric tools for practical individualized drug dosage regimens - population pk/pd modeling, multiple model (mm) dosage design, and mm bayesian adaptive control has been postponed until July 9 and 10.
We apologize for the inconvienence.

THE INTERNATIONAL ASSOCIATION FOR THERAPEUTIC DRUG MONITORING
AND CLINICAL TOXICOLOGY,
THE LABORATORY OF APPLIED PHARMACOKINETICS
at the University of Southern California School of Medicine,
and the HOSPITAL CIVIL DE GUADALAJARA, GUADALAJARA, MEXICO,
are pleased to announce:

A 2 DAY WORKSHOP ON

PHARMACOMETRIC TOOLS FOR PRACTICAL INDIVIDUALIZED DRUG DOSAGE REGIMENS - POPULATION PK/PD MODELING, MULTIPLE MODEL (MM) DOSAGE DESIGN, AND MM BAYESIAN ADAPTIVE CONTROL

THURSDAY AND FRIDAY, MAY 7- 8, 2009,

Hospital Civil de Guadalajara
Guadalajara, Mexico

FOR FURTHER INFORMATION AND FOR REGISTRATION, PLEASE CONTACT

DR. JOSE PEREZ-URIZAR, phone / fax 011-52-444-813-3986,
email = jpurizar@uaslp.mx

The Laboratory of Applied Pharmacokinetics at the University of Southern California Keck School of Medicine and the University of Kuwait School of Pharmacy are pleased to announce

a symposium on

Pharmacometric Tools for Individualized Drug Therapy: Population PK/PD Modeling, Optimal Therapeutic Drug Monitoring, Bayesian Adaptive Control, and Optimal Active "Dual" Control

February 18, 2009

The course will be held in the HSC Computer classroom at the University of Kuwait School of Pharmacy

For all relevant information, please contact

Dr. Kamal Matar

Unniversity of Kuwait School of Pharmacy

email = matar_km@yahoo.com

Objectives and Expectations:

After this conference, the participant should:

1. Understand the General approach to Target-Oriented, Model Based, Individualized Drug Therapy,

2. Understand the Clinical capabilities of Nonparametric Population Modeling.

3. Understand the need for using assay standard deviation rather than CV% in reporting lab errors.

4. Understand Multiple Model, maximally precise, Dosage Design.

5. Understand the four types of Bayesian individualization of Pharmacokinetic Models, and when to use them.

6. Become acquainted with models of bacterial growth and kill

7. Be acquainted with new approaches to optimize learning about the patient while treating him/her at the same time.

8. Be aware of recent improved outcomes using Bayesian adaptive control.

9. Apply these concepts to optimize practical therapy with Aminoglycosides, Vancomycin, Digoxin, HAART, and other drugs.

Faculty:

Dr. Roger Jelliffe, USC Laboratory of Applied Pharmacokinetics

Dr. Kamal Matar, University of Kuwait

Morning - The Library of Tools, and some Clinical Cases

8:00 AM - Registration

8:30 AM - Welcome - Dr. Matar

8:45 AM - TOOL#1 - Planning the Initial Regimen. Set a Specific Target, not a Range - Dr. Jelliffe

9:00 AM - TOOL #2 - Evaluating Renal Function

9:20 AM - TOOL #3 - Describing assay errors by Standard Deviation, not CV%

Determine the assay error polynomial

9:50 AM - TOOL #4 - Estimating Gamma, Lambda

10:00 AM - Break

10:20 AM - TOOL #5 Nonparametric Pop models

Why NP? Why not parametric? Properties, Capabilities of each

Making a population model of Amikacin

Use Boxes to make structural PK Model

Choose and check patient data files,

Enter assay error polynomial, choose gamma

Select patient files, make the model, see results

11:00 AM - TOOL #6 - Multiple Model Dosage Design

11:20 AM - TOOL #7 - Bayesian analysis

MAP, MM, Hybrid, IMM

11:40 AM - A clinical case. Enter data, plan initial gent regimen

12:00 AM - Lunch

Afternoon - More Clinical Cases

1:00 PM - Clinical Cases - Monitor a Gent Patient

Enter data, fit model to data, analyze case, select target, adjust regimen

1:45 PM - TDM on a very unstable Tobramycin patient

Load patent data, fit model, analyze result, consider IMM

2;45 PM - Using IMM Bayesian in post surgical ICU patients

3:00 PM - Break

3:20 PM - Concentration versus Time Dependent Drugs

3:30 PM - Clinical Case - Vancomycin - planning the initial regimen

A q 12 h schedule - enter data, plan the regimen

A Continuous IV infusion schedule - same thing - which is more efficient?

4:15 PM - Clinical Cases - Digoxin Therapy

Digoxin Effect correlates not with serum levels, but with Peripheral Compartment Concentrations - the Reuning Model

Planning the Initial Regimen - enter data, plan regimen

Stating serum concentration target goals

Stating Peripheral Compartment target goals

Patients with Atrial Fibrillation and Flutter

The Falk Study in Patients with Atrial Fibrillation

Two patients with Atrial Fibrillation - load patients, analyze data, plan next regimens.

4:45 PM - Outcomes with Individualized Therapy - Dr. Jelliffe

5:00 PM - Modeling Bacterial (or viral) Growth and Kill - Dr. Jelliffe

5:30 PM - Review and questions.

5:45 PM - Adjourn

The German Association of Pharmaceutical Scientists
(Deutsche Pharmazeutische Gesellschaft e.V. - DPhG)

present a Workshop on

Clinical Aspects & Applications of PK/PD
October 3, 2008, from 8:00 to 19:00

as part of the

2nd World Conference on "Magic Bullets" (Ehrlich II)
October 3 - 5, 2008
Nürnberg, Germany

For more information, please contact

Jurgen Bulitta B.Sc.
bulitta@osn.de
Pharmacokineticist
Institute for Biomedical and Pharmaceutical Research
Paul Ehrlich Street 19
90562 Nuremberg - Heroldsberg
Germany

Dr. Fritz Sorgel
ibmp@osn.de
Institute for Biomedical and Pharmaceutical Research
Paul Ehrlich Street 19
90562 Nuremberg - Heroldsberg
Germany

ClinPK1: Introduction and Overview into PK/PD for patients, Dr. Roger Jelliffe
Optimizing individualized patient therapy using nonparametric PK and PD models, multiple model (MM) dosage design, and Bayesian adaptive control.

ClinPK2: Overview and comparison of parametric and non-parametric estimation techniques, Drs. Jelliffe & J. Bulitta
Differences in algorithms used to estimate parameters of PK/PD models.

Case study 1: Clinical problems. Solving them using PK/PD Adaptive Control
MM dosage design, 4 types of Bayesian model individualization, and MM dosage adjustment.

ClinPK3: Therapeutic drug monitoring, Dr. Alexander Vinks
How therapy can be optimized by measuring drug concentrations and PK/PD modeling.

ClinPK4: Optimizing cardiovascular therapy, Dr. Jelliffe
Example for use of modeling and individual therapy optimization (e.g. for digoxin)

Case study 2: Discussion of benefits and applications of PK/PD for patient, Drs. Vinks and Jelliffe

ClinPK5: Therapeutics: optimizing learning about the patient while treating him/her at the same time, Dr. Jelliffe
How to maximize learning while treating

ClinPK6: PK/PD modeling to optimize anti-infective therapy, Dr. Alan Forrest
Transition from theory to real life: How can a physician / pharmacist apply population PK/PD models at the bedside (HIV patient examples)

Group discussion: How to implement clinical PK/PD modeling for patient care, Drs. Jelliffe and Forrest

M&S 5: Monte Carlo Simulations to predict the behavior of a whole patient population, Dr. Vincent Tam
What can we learn from incorporating between subject variability into simulations?

M&S 5: Monte Carlo Simulations to predict the behavior of a whole patient population, Dr. Vincent Tam
What can we learn from incorporating between subject variability into simulations?

Group discussion: How to integrate PK, PD, disease progression via Monte Carlo sims. Drs. Tam and Landersdorfer

(Posted 2008/09/22)

The Kuwait University Faculty of Pharmacy (Kamal Matar Ph.D.) and
The University of Southern California School of Medicine (Roger Jelliffe, M.D.)

present a Workshop on

Therapeutic Drug Monitoring and Optimal Individualized Drug Dosage
December 13, 2006, from 8:30 AM to 13:00 PM

in conjunction with the

1st Kuwait Pharmaceutical Sciences Conference and
10th Conference of Scientific Association of Colleges of Pharmacy in the Arab World

Kuwait 11 – 13 December 2006

For more information, please contact
Kamal M. Matar, B.Pharm, Ph.D.
Dept. of Applied Therapeutics, Faculty of Pharmacy,
Kuwait University, PO Box: 24923, Safat 13110, Kuwait.
Email = matar_km@yahoo.com

[Preliminary Program DOC PDF]
[Estimating CCr PPT]
[Assay and Error issues in Pop modeling and TDM PPT]
[Optimal Experimental Design PPT]
[Parametric and Nonparametric Population Modeling PPT]
[More on Parametric and Nonparametric Population Modeling PPT]
[Multiple Model Dosage Design PPT]
[Old and Newer methods for Bayesian updating PPT]
[Other PD Models linked to the basic PK Model PPT]
[TDM of Digoxin PPT]
[Related Papers PDF PDF]

(Posted 2006/10/05 Revised 2005/10/05)

Friday April 29 - Saturday April 30, Louisville, KY:
New Advances in Therapeutic Drug Monitoring and Individualized Drug Therapy.
IATDM-CT Post Congress Workshop

This workshop has been scheduled for Friday and Saturday, April 29-30, 2005.
Registration information:
Phone: (613)531-8166
Fax: (613)531-0620
Email: congress@eventsmgt.com

[Preliminary Program PDF DOC].

(Posted 2005/01/31 Revised 2005/01/31)

September 15-17, 2004 in Toulon, France:
Pharmacokinetics and Drug Therapy in the Aged Patient.
The USC Laboratory of Applied Pharmacokinetics announces its participation in an afternoon workshop on "Pharmacokinetics and Drug Therapy in the Aged Patient" in Toulon on Sept 15-17, 2004.

This workshop has been scheduled for Wednesday, Thursday and Friday, September 15-17, 2004.
Registration information can be obtained from:
Pascal Maire, Ph.D.
Hospital Antoine Charial
40, Avenue de la Table de Pierre
69340 Francheville, France
Tel 33-472-32-35-87
email - adcapt@cismsun.univ-lyon1.fr or Pascal.Maire@univ-lyon1.fr

[Preliminary Program PDF DOC].

(Posted 2004/07/20 Revised 2004/07/20)

September 7-8, 2004 in Nuremberg, Germany:
Basic Mechanisms in PK/PD & PK/PD Modeling Methods and their practical Clinical Applications
One workshop will be given by Dr. Michael Weiss of the University of Halle, Germany, and Dr. Nick Holford of Auckland, NZ. It will be oriented around "Basic Mechanisms in PK and PD".

[Preliminary Program PDF DOC].

The other workshop will be devoted to "PK/PD Modeling Methods and their practical Clinical Applications", and will be given by Roger Jelliffe of USC, George Drusano of the Ordway Research Institute, Albany NY, Ruediger Port of the German Cancer Research Institute in Heidelberg, Germany, Sander Vinks of the University of Cincinnati, and Irina Bondareva of the Laboratory of Mathematical Modeling, Research Institute for Physical-Chemical Medicine, Moscow, Russia.

[Preliminary Program PDF DOC].

Registration and more information can be obtained by contacting

Pr. Dr. Fritz Sorgel
Institute for Biomedical and Pharmaceutical Research
Paul Ehrlich Street 19
90562 Nuremberg - Heroldsberg
Germany
tel: 49-911/518-29-0
fax: 49-911/518-29-20
email: ibmp@osn.de

OR

Dr. Juergen Bulitta
Schleifweg 3
D-90562 Nuernberg - Heroldsberg
Germany
tel: +49 911 518 290
fax: +49 911 518 2920
email: j@bulitta.com

(Posted 2004/07/20 Revised 2004/07/20)

July 30-31, 2004 in Los Angeles, USA:
New Advances In Therapeutic Drug Monitoring And Model-Based, Goal-Oriented Individualized Drug Therapy.

This workshop has been scheduled for Friday and Saturday, July 30-31, 2004 at
Computer Classroom, 3rd floor, USC School of Pharmacy, 1985 Zonal Ave, Los Angeles, CA, USA

For registration information, please contact Roger Jelliffe MD(jelliffe@usc.edu).
Roger Jelliffe, MD,
USC School of Medicine,
2250 Alcazar St CSC134B,
Los Angeles CA 90033
Tel 323-442-1300, Fax 323-4442-1302

[Preliminary Program PDF DOC].

(Posted 2004/02/16 Revised 2004/02/16)

April 21-22, 2004 in Moscow, Russia:
Clinical Approaches to Individualizing Therapy with Toxic Drugs: Problem Cases and Methods for Solving them.

This workshop has been scheduled for Wednesday and Thursday, April 21-22, 2004 at
Institute for Physical and Chemical Medicine, Moscow, Russia

For registration information, please contact Irina Bondareva (ibondareva@mtu-net.ru).
Telephone: 7-095-104-1206

[Preliminary Program PDF DOC].

(Posted 2004/02/16 Revised 2004/02/16)

December 6-8, 2003 in Kuwait City, Kuwait:

This workshop has been scheduled for Saturday, Sunday, and Monday, December 6, 7, and 8, 2003

[Preliminary Program PDF DOC].

(Posted 2003/09/27 Revised 2003/09/27)

March 10-12, 2003 in Valencia, Spain:

This workshop has been scheduled for Monday, Tuesday and Wednesday, March 10, 11 and 12, 2003 at
Pharmacy and Pharmaceutical Technology Department
University of Valencia, Spain
Calle de Vicente Estelles
46100 Burjassot (Valencia) Spain

For registration information, please contact Matilde Merino (matilde.merino@uv.es).

[Preliminary Program PDF DOC].

(Posted 2003/02/18 Revised 2003/02/24)

April 8-9, 2003 in Moscow, Russia:

This workshop has been scheduled for Tuesday and Wednesday, April 8 and 9, 2003 at
The Research Institute of Physical and Chemical Medicine,
Malaya Pirogovskaya str, 1a,
Moscow, Russia.

For more information and registration please contact:
Irina Bondareva, Ph.D.
Research Institute of Physical and Chemical Medicine
Moscow 123 308
Russia
Phone = 7-095-104-1206
Email = ibondareva@mtu-net.ru

[more info].
(Posted 2003/02/19)

May 7-8, 2003 in Sofia, Bulgaria:

This workshop has been scheduled for Wednesday and Thursday, May 7 and 8, 2003 at
Clinic for Therapeutics and Clinical Pharmacology
University Hospital "Saint J. Rilsky"
Sofia, Bulgaria

For registration information, please contact:
Dimiter Terziivanov, M.D.
Clinic for Therapeutics and Clinical Pharmacology
University Hospital "Saint J. Rilsky"
15 D Nesterov St,
1431 Sofia, Bulgaria
(Email: terziiv@yahoo.com).
(Email: terz@obzor.bio21.bas.bg).
Telephone: 359-2-595-014
Fax: 359-2-595-106

[Preliminary Program PDF DOC].

(Posted 2003/02/24)

Sept 12-13, 2003, Basel, Switzerland:

This workshop has been scheduled for Friday and Saturday, Sept 12 and 13, 2003 in
Basel, Switzerland in conjuction with the International Congress on Therapeutic Drug Monitoring and Clinical Toxicology in Basel, Sept 8-11, 2003.

For registration information, please contact:
Rosemarie B. Marty.
Congress Plus GmbH.
Haltingerstrasse 104
CH-4057 Basel, Switzerland.
(Email: info@congress-plus.ch).
(Email: ehooper@eventsmgt.com).
(Email: office@iatdmct.org).

Tel:41-61-683-1382
Fax:41-61-683-1383

[Preliminary Program PDF DOC].

(Posted 2003/02/24)

Jan 23 2003 in Orlando, Florida:

The USC Laboratory of Applied Pharmacokinetics is pleased to announce a 1 Day workshop on
Principles of Pharmacokinetics - New Unified Approaches to Parametric and Nonparametric
Population PK and PD Modeling - Applications to Therapeutic Drug Monitoring and to
Optimal individualization of Drug Therapy and cancer chemotherapy.
[more info]

(Posted 2002/07/16)

Dec 3 2002 in Rovigo, Italy:

The USC Laboratory of Applied Pharmacokinetics and the International
Cancer Center, Rovigo, Italy, are pleased to announce a 1 Day workshop
on new Unified Approaches to Parametric and Nonparametric Population PK and
PD Modeling - Applications to Therapeutic Drug Monitoring and to Optimal
individualization of Drug Therapy and cancer chemotherapy.
[more info]

(Posted 2002/07/16)

Nov 29 2002 in Lyon, France:

The USC Laboratory of Applied Pharmacokinetics and the UMR CNRS 5558 "Biomitrie et
Biologie ivolutive / Biologie des Populations / Modilisation et Pharmacocinitique
appliquie" are pleased to announce a One-Day, Hands-on workshop on principles of Pharmacokinetics.
New Unified Parametric and Nonparametric Approaches to Population PK and PD Modeling.
Applications to Therapeutic Drug Monitoring and to Optimal individualization of Drug
Therapy.
[more info]

(Posted 2002/09/16)

Sep 30 2002 in Los Angeles, USA:

The USC Laboratory of Applied Pharmacokinetics is pleased to announce
an upcoming workshop September 30 through October 2, 2002.
[more info]

(Posted 2002/06/24)

Jan-May 2002:

The USC Laboratory of Applied Pharmacokinetics is pleased to announce five new PK/PD workshops for the first half of 2002. They are:

1. January 24-26, in Pamplona, Spain (a hands-on workshop) [registration closed]

2. February 21-23, here at USC (also a hands-on workshop) [registration closed]

3. March 19-22, in Turin, Italy (also a hands-on workshop)

4. April 8-12, in Moscow, Russia [registration closed]

5. May 15-17, in St. Petersburg, Russia [registration closed]

(Posted 2001/12/10)

2001/09/27-29:
A Hands-on Workshop on Parametric and Nonparametric Population PK and PD Modelling and its Applications in Therapeutic Drug Monitoring

Due to the recent catastrophic events in New York and Washington, this workshop has now been rescheduled for Thursday, Friday, and Saturday, January 24, 25, and 26, 2002.

~~Thursday through Saturday, September 27-29, 2001, University of Navarra, Pamplona, Spain.~~

This course is intended for physicians, pharmacists and all biomedical scientists with an interest in population pharmacokinetic/pharmacodynamic modelling and also for those interested in therapeutic drug monitoring and optimal individualization of drug therapy for patient care. Prior experience in clinical pharmacokinetics will be an advantage. Participants will be introduced to the USC*PACK software program which can be used both for therapeutic drug monitoring as well as for parametric and nonparametric population PK/PD and physiological modelling.

For registration information, please contact Dra. Azucena Aldaz (aaldaz@unav.es).

A revised program is available.

(Posted 2000/12/19, revised 2001/09/19)

2001/09/7-8:
A two day workshop on "Therapeutic Drug Monitoring for Model-Based, Goal-Oriented Optimal Individualized Drug Therapy:

Relationship to Parametric and Nonparametric Population PK/PD Modelling and to Multiple Model Dosage Design" on September 7-8, 2001, just after the International Congress on Therapeutic Drug Monitoring and Clinical Toxicology, September 1-6, 2001. Location: The Mayflower Hotel, Washington DC, USA.

This course is intended for physicians, pharmacists, clinical toxicologists and biomedical scientists with an interest in population pharmacokinetic and pharmacodynamic modelling and in therapeutic drug monitoring and optimal individualization of drug therapy for patient care. Prior experience in clinical pharmacokinetics will be an advantage. Participants will be introduced to the USC*PACK and NONMEM software programmes which can be used both for therapeutic drug monitoring as well as for parametric and nonparametric population PK/PD and physiological modelling.

For registration information, please contact Mrs. Elizabeth Hooper (ehooper@eventsmgt.com).

A revised program is available.

(Posted 2000/12/19)

2001/06/26-28:
Tenth Workshop 2001 on Adaptive Control of Drug Therapy

June 26-28, 2001, Lyon, France.

This workshop in applied pharmacokinetics is organized ADCAPT (Hospices Civils de Lyon) and the Laboratory of Applied Pharmacokinetics of the University of Southern California School of Medicine. It is designed for clinicians, practitioners, and those in the industry who are interested in the need to manage, control, and minimize the variability of various potentially toxic drugs and medications. This work utilizes the work, concepts, and both the clinical and research software developed jointly by ADCAPT since 1986 and by USC since 1967.

For registration information, please contact the workshop secretariat (adcapt@cismsun.univ-lyon1.fr).

More information is available.

(Posted 2001/02/06)

2001/06/26-28:
Basic Applications of Pharmacokinetics to Optimal Patient Care: How to do it with a laptop computer at the bedside.

April 9-10, 2001, Moscow, Russia.

This course is for physicians and pharmacists with an interest in population pharmacokinetic/dynamic modeling who have a grasp of the basic aspects of such work. Day 1 will introduce and review Basic PK/PD tools and concepts of pharmacokinetic modeling, and will emphasize their application to optimal patient care. Day 2 will discuss intermediate and advanced PK/PD tools, and concepts, including parametric and nonparametric population modeling.

Note: Participants planning to come from outside Russia should allow at least one month in order to obtain a visa for entry into Russia.

For registration information, please contact Irina Bondareva (lidos@aha.ru).

More information is available.

(Posted 2001/02/06)

2001/03/29-30:
A talk on "Optimizing the Design of Individualized Drug Dosage Regimens for Maximal Precision"

at the Institute for International Research conference on "Clinical PK/PD for Drug Development" March 29 and 30, 2001, at the Park Hyatt Hotel in Philadelphia PA.

More info can be found at the IIR conference website.

At the same conference: A panel discussion on Targeted versus Individualized Drug Therapy.

The talk will discuss strengths and weaknesses of various methods of modeling drug behavior, including linear regression, weighted nonlinear least squares regression, maximum aposteriori probability (MAP) Bayesian fitting, and the new interacting multiple model sequential Bayesian parameter updating, which is designed to detect changing parameter values during the period of data analysis.

Parametric and nonparametric population modeling approaches which are relevant to these approaches will also be discussed, and their strengths and weaknesses. Optimal procedures for weighting clinical data will also be discussed. In particular, the relationships between parametric and nonparametric population PK/PD models and the types of dosage regimens that can be developed will be discussed, along with their strengths and weaknesses. Current methods of dosage design will be compared with the new "multiple model" method, which hits desired target goals with maximum predicted precision.

(Posted 2000/12/19)

2001/02/27-28:
A talk on "Optimal Techniques and Sequences for Population Modeling of Bioavailability"

at the Conference on Bioavailability and Bioequivalence, to be held on February 27 & 28, 2001 in Washington, DC. The goal of this meeting is to address the issues and questions surrounding Bioavailability and Bioequivalence and better educate the industry on how to best model BA and BE.

Their web site is http://www.barnettinternational.com/.
The conference schedule is available in .pdf format.

A brief abstract of the talk is below. A powerpoint file is also attached:

It is no longer necessary to evaluate bioavailability by the traditional method of comparing areas under the curve between oral and IV routes, with a washout in between, and a crossover strategy. Instead, one can directly compute bioavailability from a drug regimen containing an mixture of IV and oral doses. In this way, there is much less chance for parameter values to change between administration of the doses. Further, one can obtain this information directly from patients under treatment, those who will need this information the most, rather than as a research project done usually on normal volunteers. Thus bioavailability can be evaluated during actual therapy and patient care. Population models can be made which permit direct use of this data in further optimizing such care.

[ View PowerPoint file ]

(Posted 2000/12/19)

2001/01/09:
An evening workshop on "Current Issues in Pharmacometrics: Optimal Modeling and Therapy"

by Roger Jelliffe, M.D., Laboratory of Applied Pharmacokinetics, USC Keck School of Medicine, and Nils Hoem, Ph.D., School of Pharmacy, University of Oslo, Norway.

The workshop takes place on Tuesday, January 9 2001 from 07:00-10:00 PM (time is tentative), during the Western Multiconference 2001 (International Conference on Health Sciences Simulation) at the Crowne Plaza Hotel, Phoenix AZ, January 7-11, 2001.

This workshop is designed for physicians, pharmacists, and scientists interested in studying the behavior of drugs in patients and animals, and in applying that information to regulatory agencies and to optimal patient care. A basic, but not an advanced, knowledge of pharmacokinetics, experimental design, and therapeutic drug monitoring will be useful.

A preliminary program is available.

(Posted 2000/11/27)

2000/11/16:
Proceedings from the November workshop are now available

The final program, a complete list of faculty and participants, plus related slides and documents can be found here.
See also Publications and information.

[ current announcements ]

Laboratory of
Applied Pharmacokinetics

  School of Medicine
  University of Southern California
  CSC 134-B
  2250 Alcazar Street
  Los Angeles, CA 90033

  Telephone: (323) 442-1300
  Fax: (323) 442-1302

Email: contact@lapk.org
URL: www.lapk.org