Recent Presentations

  1. Jelliffe R, Schumitzky A, Bayard D, Leary R, Thomson A, Botnen A, and Neely M: Pharmacometric Tools to Optimize Drug Therapy. A poster presentation at the Quantitative and Systame Biology Workshop, Lister Hill Auditorium, Bethesda MD, September 25-26, 2008.

  2. Jelliffe R, Schumitzky A, Bayard D, Botnen A, Neely M, and Thomson A: Multiple Model Dosage Design, and a new IMM Sequential Bayesian Method for Updating Individual Patient PK/PD Models. A Poster presentation at the CPT2008 International Meeting, July 27 – August 1, 2008, Quebec, Canada.

  3. Jelliffe R, Schumitzky A, Bayard D, Van Guilder M, Botnen, A, Neely, M, Thomson A and Bustad A: The USC*PACK BigWinPops and MM-USCPACK Programs, USC Laboratory of Applied Pharmacokinetics (www.lapk.org). A software presentation at the Population Approach Group Europe meeting, June 18-20, 2008, Marseille, France.

  4. Goutelle S, Bourguignon L, Maire, P.H., Van Guilder M, Jelliffe R, and Conte J.E. : Influence of Rifampin Pharmacokinetic Variability on Antibacterial Effect and Prevention of Resistance in Pulmonary Tuberculosis: a Simulation Study. A poster presentation at the Population Approach Group Europe meeting, June 18-20, 2008, Marseille, France.

  5. Goutelle S, Bourguignon L, Maire, P.H., Van Guilder M, Jelliffe R, and Conte J.E: A Population Pharmacokinetic Study of Plasma and Intrapulmonary Concentrations of Rifampin. A poster presentation at the Population Approach Group Europe meeting, June 18-20, 2008, Marseille, France.

  6. "Bulitta JB, Landersdorfer CB, Schumitzky A, Van Guilder M, Jelliffe RW. Comparison of Bias and Precision of Nonparametric and Parametric Population Methods assessed via Nonparametric Bootstrap Methods in NPAG and NONMEM. American Conference on Pharmacometrics (ACoP), Tucson, Arizona, March 9-12, 2008. "

  7. "Landersdorfer CB, Bulitta JB, Schumitzky A, Van Guilder M, Jelliffe RW. Comparison of Nonparametric and Parametric Population Methods based on a Monte Carlo Simulation Study with Indirect Response Models I to IV in NPAG and NONMEM. American Conference on Pharmacometrics (ACoP), Tucson, Arizona, March 9-12, 2008. "

  8. Neely M and Jelliffe R: Population Pharmacokinetic Models and Individualized Bayesian Dose Optimization in HIV Patients. A poster presentation at the American Conference on Pharmacometrics, Tucson AZ, March 8, 2008.

  9. Kwa A, Sprung J, Van Guilder M, and Jelliffe R: A Population Pharmacokinetic Model of Epidural Lidocaine in Geriatric Patients: Effects of Low – Dose Dopamine. Presented at the Population Approach Group Europe meeting, June 13-14, 2007, Copenhagen, Denmark.

  10. Premaud A, Van Guilder M, Armstrong V, Weber L, Gandhi A, Oellerich M,Tonshoff B, Jelliffe R, Marquet P, and Rousseau A: Population pharmacokinetics and Bayesian estimation of mycophenolate mofetil in paediatric renal transplant recipients using a nonparametric approach. Presented at the Population Approach Group Europe meeting, June 13-14, 2007, Copenhagen, Denmark.

  11. Neely M, Rakhmanina N, Van Den Anker J, Soldin S, Van Guilder M, Schumitzky A, and Jelliffe R: Impact of Lopinavir Limit of Quantification (LOQ) Censored Data Replacement onj Population Pharmacokinentic (PK) Plasma and Saliva Modeling in HIV Infected Children. Presented at the Population Approach Group Europe meeting, June 13-14, 2007, Copenhagen, Denmark.

  12. Jelliffe R, Schumitzky A, Bayard D, Van Guilder M, Gandhi A, Neely M, and Bustad A: The USC*PACK collection of BigWinPops software for nonparametric adaptive grid (NPAG) population PK/PD modeling, and the MM-USCPACK clinical software for maximally precise dosage regimens and patient care. Presented at the Population Approach Group Europe meeting, June 13-14, 2007, Copenhagen, Denmark.

  13. Kwa A, Sprung J, Van Guilder M, and Jelliffe R: APopulation Pharmacokinetic Model of Epidural Lidocaine in Geriatric Patients: Effects of Low – Dose Dopamine. Presented at the Pharmacokinetics Section, XIV Annual Meeting of “Chelovek i Lekarstvo” (Man and Drugs), Moscow, Russia, April 18, 2007.

  14. Jelliffe R, Schumitzky A, Bayard D, Van Guilder M, and Leary R: The USC*PACK Programs for Parametric (PEM) and Nonparametric Population (NPAG) PK/PD Modeling, for Multiple Model Adaptive Control of Drug Dosage Regimens, and for IMM Bayesian Posterior Individual Models with Changing Parameter Distributions during the period of Data Analysis. Population Analysis Group in Europe, Bruges, Belgiom, June 14-16, 2006.

  15. Bustad A, Terziivanov D, Leary R, Port R, and Jelliffe R: Parametric and Nonparametric Population Modeling – an Impression and a Fact about Parameter Precision. A poster presentation at the International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Louisville KY, April 27, 2005.

  16. Leary R, Jelliffe R, Schumitzky A, and Port R: Accurate Maximum Likelihood Estimation for Parametric Population Analysis. 13th meeting, Population Analysis Group in Europe, Uppsala, Sweden, June 17-18, 2004. Proceedings, p. 12.

  17. Leary R, Jelliffe R, Schumitzky A, and Port R: Accurate vs. Approximate Likelihood Methods in Population Analysis of Sparse Data Sets. 2004 Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, March 24-27, 2004, Miami FL. Clin. Pharm. Therap. 75: P30, 2004.

  18. Leary R, Port R, Schumitzky A, and Jelliffe R: New Methods for Statistically Consistent and Efficient PK/PD Population Estimation, A poster at the International Congress on Therapeutic Drug Monitoring and Clinical Toxicology, Basel, Switzerland, September 7-11. 2003.

  19. Leary R, Jelliffe R, Schumitzky A, and Van Guilder M: Improved Computational Methods for Statistically Consistent and Efficient PK/PD Population Analysis. Presented at the Annual Meeting of the Population Approach Group in Europe, Verona, Italy, June 12-13, 2003.

  20. Carlsson K, Hansen H, Jelliffe R, and Hoem N: Establishing a tool for individualised dosing of gabapentin – The use of a non-parametric population kinetic model in the MM-USC*PACK software, a new tool for clinical dosage optimization. Presented at the Annual Meeting of the Population Approach Group in Europe, Verona , Italy, June 12-13, 2003.

  21. Berges A, Petersen C, and Jelliffe R: Gentamicin Ototoxicity: Characteristics of Patient Response Analyzed with Saturable Michaelis-Menten Models. Presented at the 4th International Meeting on Mathematical Modeling, Technical University of Vienna, Vienna, Austria, February 6, 2003.

  22. Bondareva A, and Jelliffe R: Modeling of Nonlinear Pharmacokinetics of Phenyoin, and of Carbamazepine during its Autoinduction Period. Presented at the 4th International Meeting on Mathematical Modeling, Technical University of Vienna, Vienna, Austria, February 6, 2003.

  23. Jelliffe R, Bayard D, Schumitzky A, Milman M, Jiang F, Leonov S, Gandhi A, and Botnen A: A New Clinical Software Package for Multiple Model (MM) Design of Drug Dosage Regimens for Planning, Monitoring, and Adjusting Optimally Individualized Drug Therapy for Patients. Presented at the 4th International Meeting on Mathematical Modeling, Technical University of Vienna, Vienna, Austria, February 6, 2003.

  24. Jelliffe R, Schumitzky A, Bayard D, Milman M, Botnen A, and Van Guilder M: Optimizing Individualized Drug Therapy with Nonparametric Population Models and Multiple Model Bayesian Adaptive Control. Presented at the 12th International Workshop on Dynamics and Control, Sheraton Universal Hotel, Universal City, CA, August 19-21, 2002.

  25. Leary R, Jelliffe R, Schumitzky A, and Van Guilder M: A Unified Parametric/Nonparametric Approach to Population PK/PD Modeling. Presented at the Annual Meeting of the Population Approach Group in Europe, Paris, France, June 6-7, 2002.

  26. Jelliffe R, Schumitzky A, Bayard D, Van Guilder M, and Leary R: The USC*PACK Programs for Parametric and Nonparametric Population PK/PD Modeling, for Multiple Model Adaptive Control of Drug Dosage Regimens, and for IMM Bayesian Posterior Individual Models with Changing Parameter Distributions during the period of Data Analysis. Population Analysis Group in Europe, Paris, France, June 6-7, 2002.

  27. Bustad A, Jelliffe R, and Terziivanov D: A comparison of Parametric and Nonparametric Methods of Population Pharmacokinetic Modeling. A poster presentation at the Annual Meetings of the American Society for Clinical Pharmacology and Therapeutics, Atlanta, GA, March 26, 2002.

  28. Botnen A, Wang X, Jelliffe R, Thomas M, and Hoem N: Population Pharmacokinetic/Dynamic Modeling Via the World Wide Web. A poster presentation at the Seventh International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Mayflower Hotel, Washington, DC, September 4, 2001.

  29. Leary R, Jelliffe R, Schumitzky A, and Van Guilder M: Maximum Likelihood Estimation of Inter- and Intra- Individual Variability in PK/PD Population Analysis. A poster presentation at the Seventh International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Mayflower Hotel, Washington, DC, September 4, 2001.

  30. Hoem N. and Jelliffe R: Modeling Oral Absorption as a Cumulative Weibull Function – Use in an NPEM Population Pharmacokinetic Model of Ciclosporine. A poster presentation at the Seventh International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Mayflower Hotel, Washington, DC, September 4, 2001.

  31. Bleyzac N, Souillet G, Magron P, Janoly A, Martin P, Bertrand Y, Galambrun Y, Maire P, Jelliffe R, and Aulagner G: Improved Outcome with Individualized Bayesian Busulfan (B) Dosage Regimens. A poster presentation at the Seventh International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Mayflower Hotel, Washington, DC, September 3, 2001.

  32. Bayard D, Botnen A, Shoemaker W, and Jelliffe R: Stochastic Analysis of Therapeutic Modalities Using a Database of Patient Responses. Presented at the 14th IEEE Symposium on Computer Based Medical Systems, July 26-27, 2001, Bethesda MD. Proceedings, pp. 439-444.

  33. Shoemaker W, Wo C, Botnen A, Bayard D, and Jelliffe R: Development of a Hemodynamic Database in Severe Trauma Patients to Define Optimal Goals and Predict Outcome. Presented at the 14th IEEE Symposium on Computer Based Medical Systems, July 26-27, 2001, Bethesda MD. Proceedings, pp. 231-236.

  34. Botnen A, Jelliffe R, Thomas M, and Hoem N: Population Pharmacokinetic/Dynamic Modeling via the World Wide Web. Presented at the 14th IEEE Symposium on Computer Based Medical Systems, July 26-27, 2001, Bethesda MD. Proceedings, pp. 163-168.

  35. Leary R, Jelliffe R, Schumitzky A, and Van Guilder M: An Adaptive Grid Nonparametric Approach to Pharmacokinetic and Dynamic (PK/PD) Population Models. Presented at the 14th IEEE Symposium on Computer Based Medical Systems, July 26-27, 2001, Bethesda MD. Proceedings, pp. 389-394.

  36. Jelliffe R, Bayard D, Schumitzky A, Milman M, Jiang F, Leonov S, Gandhi V, Gandhi A, and Botnen A: Multiple Model (MM) Dosage Design – Achieving Target Therapeutic Goals with Maximum Precision. Presented at the 14th IEEE Symposium on Computer Based Medical Systems, July 26-27, 2001, Bethesda MD. Proceedings, pp. 23-28.

  37. Jelliffe R, Schumitzky A, Van Guilder M, Wang X, and Leary R: Population Pharmacokinetic and Dynamic (PK/PD) Models. Parametric (P) and Nonparametric (NP) Approaches. Presented at the 14th IEEE Symposium on Computer Based Medical Systems, July 26-27, 2001, Bethesda MD. Proceedings, pp. 407-412.

  38. Charpiat B, Gouy L, Ducerf C, Fourcade N, Doyen C, Baulieux J, and Jelliffe R: What is the Usefulness of Tacrolimus Whole Blood Concentrations measured with Microparticle Enzyme Immunoassay for Liver Transplant Patients? Presented at the EPHAR 2001 Meeting of the Federation of the European Pharmacological Societies, Lyon, France, July 6-9, 2001.

  39. Hoem N, and Jelliffe R: An NPEM Population Analysis of Ciclosporine – Modelling Oral Drug Absorption as a Time-Dependent Function. Presented at the Annual Meeting of the Population Analysis Group in Europe, Basel, Switzerland, June 7-8. 2001

  40. Bleyzac N, Souillet G, Magron P, Janoly A, Martin P, Bertrand Y, Galambrun C, Maire P, Aulagner G, and Jelliffe R: Reduced Transplant-Related Mortality by Bayesian Individualization of Busulfan Dosage in Children. Presented at the Annual Meeting of the Population Analysis Group in Europe, Basel, Switzerland, June 7-8. 2001

  41. Botnen A, Wang X, Jelliffe R, Thomas M, and Hoem N: Population Pharmacokinetic Modeling via the World Wide Web. Presented at the Annual Meeting of the Population Analysis Group in Europe, Basel, Switzerland, June 7-8. 2001

  42. Van Guilder M, Leary R, A Schumitzky A, and Jelliffe R: A Bootstrap Algorithm for Confidence Limits for Nonparametric Population Models. Presented at the Annual Meeting of the Population Analysis Group in Europe, Basel, Switzerland, June 7-8. 2001.

  43. Leary R, Jelliffe R, Schumitzky A, and Van Guilder M: New Advances in Nonparametric PK/PD Population Modeling. Presented at the Annual Meeting of the Population Analysis Group in Europe, Basel, Switzerland, June 7-8. 2001.

  44. Kwa A, Sprung J, and Jelliffe R: Population Pharmacokinetic and Pharmacodynamic Modeling of 3-Compartment Epidural Lidocaine in Geriatric Patients. Presented at the 2001 Spring Practice and Research Forum, American College of Clinical Pharmacy, Salt Lake City, UT, April 22-25, 2001.

  45. Leary R, Jelliffe R, Schumitzky A, and Van Guilder M: Nonparametric Pharmacokinetic/Dynamic Population Modeling with Adaptive Grids. Presented at the Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Orlando, FL, March 6-10, 2001, Proceedings, p. P58.

  46. Bayard D and Jelliffe R: Bayesian Estimation of Posterior Densities for Pharmacokinetic Models having Changing Parameter Values. Presented at the. 29th Annual Meeting of the American College of Clinical Pharmacology, Chicago IL, September 18, 2000.

  47. Jelliffe R and Bayard D: Bayesian Estimation of Posterior Densities for Pharmacokinetic Models having Changing Parameter Values. Presented at the Annual Meetings of the Population Analysis Group in Europe, Salamanca, Spain, June 15-16, 2000.

  48. Jelliffe R, Bayard D, Schumitzky A, Milman M, Jiang F, Leonov S, and Gandhi V: Multiple Model (MM) Dosage Design: Achieving Target Goals with Maximum Precision. Presented at the 3rd IMACS Symposium on Mathematical Modelling, February 2-4, 2000, Vienna University of Technology, Vienna, Austria. Published in the Proceedings, pp.577-582.

  49. Jelliffe R, Schumitzky A, Van Guilder M, Wang X, and Leary R: Population Pharmacokinetic Models: Parametric and Nonparametric Approaches. Presented at the 3rd IMACS Symposium on Mathematical Modelling, February 2-4, 2000, Vienna University of Technology, Vienna, Austria. Published in the Proceedings, pp.571-575.

  50. Bayard D and Jelliffe R: Bayesian Estimation of Posterior Densities for Pharmacokinetic Models having Changing Parameter Values. Presented at the Annual Meetings of the Society for Computer Simulation, San Diego CA, January 23-27, 2000. Published in the Proceedings, Health Sciences Simulation, pp. 75-83.

  51. Bayard D and Jelliffe R: Bayesian Estimation of Posterior Densities for Pharmacokinetic Models having Changing Parameter Values. Presented at the International Conference on Health Sciences Simulation, 2000 Western Multiconference, San Diego, CA, January 25, 2000. Published in the Proceedings of the Society, pp. 75-83.

  52. R. Jelliffe, A. Schumitzky, M. Van Guilder, X. Wang, and R. Leary. Population Pharmacokinetic Models: Parametric and Nonparametric Approaches. Presented at the 3rd IMACS Symposium on Mathematical Modeling, Vienna Institute of Technology, Vienna, Austria, February 3, 2000. Published in the Proceedings, Volume 2, pp.571-575. [ .pdf ]

  53. R. Jelliffe, D. Bayard, A. Schumitzky, M. Milman, F. Jiang, S. Leonov, and V. Gandhi. Multiple Model (MM) Dosage Design: Achieving Target Goals with Maximum Precision. Presented at the 3rd IMACS Symposium on Mathematical Modeling, Vienna Institute of Technology, Vienna, Austria, February 3, 2000. Published in the Proceedings, Volume 2, pp.577-582. [ .pdf ]

  54. R. W. Jelliffe, M. Van Guilder, R. Leary, A. Schumitzky, X. Wang, and A. Vinks. Nonlinear Parametric and Nonparametric Population Pharmacokinetic Modeling on a Supercomputer. Jan. 25, 1999. [ .pdf ]