|Laboratory of Applied Pharmacokinetics
Optimizing drug therapy for populations and individual patients
The USC Laboratory of Applied Pharmacokinetics (LAPK) of the Keck School of Medicine at the University of Southern California is a pharmacometric resource for optimal study and control of pharmacokinetic/pharmacodynamic systems and for individualized drug therapy and personalized medicine. It is currently supported by grants from The National Institute for General Medical Studies (GM068968), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD070996).
Our research activities include: application of stochastic control theory to the design of optimal dosage regimens; improved methods for population pharmacokinetic modeling; investigation of process and measurement noise in the clinical environment; evaluation of alternative parameterizations of pharmacokinetic models; optimal monitoring strategies for pharmacokinetic studies, clinical trials. Examples of current clinical trials sponsored by our lab include the characterizing the developmental pharmacology of voriconazole in children and optimized vancomycin dosing with BestDose, our multiple-model, Bayesian Adaptive Control software.
Software is available for use in pharmacokinetics research applications. Current computer programs include:
The software and expertise can be made available, with approval, to researchers for collaborative projects or as a technical service.