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Laboratory of Applied Pharmacokinetics Optimizing drug therapy for populations and individual patients |
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Laboratory of Applied Pharmacokinetics Optimizing drug therapy for populations and individual patients |
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We now have an update that makes the USC*PACK programs Y2K compatible. It is a new version of the PASTRX.EXE program for entry of patient data. All years from 80 through 99 are now 1980 through 1999, and all years from 00 through 79 are 2000 through 2079, thus making everything compatible through the year 2079.
This new version, done by Dr. Xavier Barbaut, of Hospices Civils de Beaune, and ADCAPT, Hospices Civils de Lyon, France, also contains several new features as well. When preparing data for the General Modeling, Bayesian Fitting program (which now includes the data files for IT2B and NPEM population modeling, including that done on the Cray T3E parallel machine at the San Diego Supercomputer for large and nonlinear PK/PD models, one can now enter and store up to 6 separate responses such as serum concentrations and any other assay (metabolites, for example) or measured effect responses, and multiple extra descriptors or covariates to examine for their relationships to the PK/PD parameters.
These covariates are of three types:
1. A yes/no covariate such as smoker/nonsmoker
2. A numerical covariate, such as heart rate or systolic or diastolic BP, or peak expiratory flow rate, for example, which remains constant at the stated value until the next such value is entered.
3. A numerical covariate, similar to the above ones, but where the investigator wants the value to change in a linear manner from the first stated value to the second, and so on. Here, the value of the covariate at the time each dose is given will be computed by linear interpolation between the stated values.
If you want to download this program, you might consider copying your current version of PASTRX.EXE to another name, just in case you might wish to recover it later on. If you do not do this, the new version of PASTRX.EXE will be written over the old one. Its companion file, PASTRX.CRC (for doing cyclic redundancy checks on the integrity of the executable code, will also be downloaded and will overwrite the old PASTRX.CRC.
Now, specify the directory, such as c:\USCPACK, into which you want the new version to be downloaded.
Now, click on the links, PASTRX.EXE and PASTRX.CRC, to download the program and its crc file into that directory.